Dapoxetine, a rapidly absorbed SSRI with a short half-life, has received the most attention of the investigational agents for PE. Despite receiving a non-approvable letter from FDA in 2005, dapoxetine is in phase 3 studies and is currently available in several European countries. Unfortunately the SSRIs BMS-505130 and UK-390957, which had shown some initial promise, no longer appear to be under development.44 The proposed rationale behind the development of the 5-HT1A antagonists for PE is that the coadministration of these agents with the SSRIs may improve the onset of effect in patients who are utilizing on-demand treatment. Combination treatment with pindolol (a non-selective beta blocker with known 5-HT1A antagonist properties) and paroxetine was shown to improve IELT, weekly intercourse episodes, and satisfaction in PE patients who were refractory to paroxetine monotherapy.45 However, combination therapy was also associated with significantly more side effects, which is consistent with the poor tolerability of non-selective beta blockers. Despite several studies that have evaluated the use of sildenafil, vardenafil, or tadalafil, substantial data to support the efficacy of these agents in men with PE, who do not have coexisting ED, is lacking.46
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There are several theories as to the cause of PE: One study blamed hyperactive pubococcygeal muscles, while some sex therapists attribute it to early conditioning—furtive, fast masturbation. “There’s this extremely vivid image I have,” Allen recalls, “of sitting on my parents’ bed looking through my father’s stack of porn magazines and half looking over my shoulder to make sure my brother wasn’t coming down the hall or, God forbid, my parents weren’t coming home. It was, you’d better finish quickly before you get caught.”
I am 25 years old and i m suffering from premature ejaculation. My penis is very small and thin and very sensitive. I get too much anxiois when i see any sex video or any hot picture. When i try to have sex with my girl friend i discharge within 20 seconds … Even getting too much excited sometimes i discharge in pants too….sir please help me in getting a longer stronger an thinner penis and to last long on bed while having sex. I want to enjoy long time in bed but i can’t. Please sir help me by providing ur valuable suggestion and off course homoeopathic remedies for this problem…
Sir im suffering from premature ejaculation and night fall also. Im 28 yrs . My penis became small and thin due to the masturbation . Sex time is less than 1 mnt . I would like to take some homeopathic medicine . Suggest me about it. Will small penis effects on my marriage life . Im single right now. Can i spend happly married life after homeopathic care. My semen is also thin sir .help me and give me some good medicine name.
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Erectile and ejaculatory disorders comprise the most prevalent sexual disorders in men, with erectile dysfunction (ED) primarily affecting aging men who have coexisting morbidities such as cardiovascular disease and diabetes mellitus. Premature ejaculation (PE) can affect men of all ages and is not typically associated with underlying organic disorders but is believed to be associated with imbalances in serotonin neurotransmission.
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Homeopathic medicine for premature ejaculation can be divided with their symptoms such as weakness, diminished libido, diminished power, impotency and sexual excesses (loss of memory, impaired coordination, numbness and tingling in limbs, irresistible desire for masturbation, constant dwelling on sexual subjects and excitable even before the sexual stimulation starts):