Dapoxetine, a rapidly absorbed SSRI with a short half-life, has received the most attention of the investigational agents for PE. Despite receiving a non-approvable letter from FDA in 2005, dapoxetine is in phase 3 studies and is currently available in several European countries. Unfortunately the SSRIs BMS-505130 and UK-390957, which had shown some initial promise, no longer appear to be under development.44 The proposed rationale behind the development of the 5-HT1A antagonists for PE is that the coadministration of these agents with the SSRIs may improve the onset of effect in patients who are utilizing on-demand treatment. Combination treatment with pindolol (a non-selective beta blocker with known 5-HT1A antagonist properties) and paroxetine was shown to improve IELT, weekly intercourse episodes, and satisfaction in PE patients who were refractory to paroxetine monotherapy.45 However, combination therapy was also associated with significantly more side effects, which is consistent with the poor tolerability of non-selective beta blockers. Despite several studies that have evaluated the use of sildenafil, vardenafil, or tadalafil, substantial data to support the efficacy of these agents in men with PE, who do not have coexisting ED, is lacking.46

I am 34 year male recently got married couple of months ago, i have too early ejaculation problem while during intercourse last only few seconds (2 or 3) and sometimes before even entering vagina!! I have hard erection during foreplay but when it comes to have intercourse i lose my erection..i used some sildenfil citrate tablet before intercourse which made me erect while penetrating inside the vagina..and it worked!! but it lasted only few seconds and i discharged too quick!! 🙁 i didnt have this erection problem earlier but facing it for a month.. for your info, i used to masturbate since my early age (rubbing my penis with my matix on my bed), for many years i masturbated once in a week and sometimes once in a fortnight.. i urinate excessively whenever drink any liquid (Tea,water,soft drink etc etc) and also i dont have my bowls on daily basis (sometimes daily sometimes after 1 day gap) kind of constipation problem..i have allergy problem as well and catch flu very quick..hair are also falling excessively due to this flu thing.
Premature ejaculation can be subdivided into a primary or secondary disorder, and although the underlying etiology is not completely known, accumulating evidence supports the role of a neurophysiologic and/or behavioral disease component.5,7,40 Patients with primary premature ejaculation (PPE) have features consistent with a neurophysiologic focus including family history of PE, penile hypersensitivity, excessive ejaculatory reflex, and serotonin receptor sensitivity.40 Stress, anxiety, and emotional problems are consistent with a behavioral theory and have been more closely associated with secondary PE. Several neurotransmitters have been implicated for their role in the complex process of the ejaculatory reflex, with serotonin exhibiting an inhibitory role during ejaculation.41
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I am married for last 4 years. We are trying for baby for last 3 years. But without any success. I use to masturbate very much before marrige. Now my semen is very watery and thin. It even looks like water with very slight milky white colour. And the quantity of semen is also low and the errection is weak. Is there any homeopathic madecine for my problem.
Sir, i have premature ejaculation. I start masturbate when i was 11 years old and doing masturbate regularly 2 times a day for six years. When i stop masturbate then so many problems came nightfall, semen pass in urine and sometimes burning sensation in urine. Now i am married before two years and suffering from premature ejaculation and semen pass in urine. I have no children. Sir pls suggest any medicine for my illness, recover vigour and vitality and fertility.
February 16, 2009  |  abchomeopathy.com "Less Erection,Premature Ejaculation And Couldnt Control Hungry - ABC Homeopathy Forum - Less Erection,Premature ejaculation and couldnt control hungry ...Less Erection,Premature ...Other problems are i couldn't control my hunger if i m feeling hungry i feel bit tremor and kind of very tiredness but im taking good food everything is perfect.i have tested thyroid and diabetic(bllod sugar) both are normal." Comment Helpful? Save
In the simplest terms, premature ejaculation occurs when a man does not have control over ejaculation, and as a result, he and his partner are not sexually satisfied, says Dr. Kramer. Premature ejaculation can happen in as little as 30 seconds to a minute, and may even occur before penetration. Contrary to the unrealistic depictions seen in pornographic films, the average time it takes before a man ejaculates during intercourse is about four to five minutes, says Kramer.
Hi sir,I am 38 years and i have got married before 8 years. I have a son and 2 daughters.I had a bad habbit of mastribution since long.now I am in fall of premature Ejaculation since marriage. I am discharge at the beginning of foreplay. I have used many medicines along with anti depressent.but no medicine have effect me yet.I have also used homeopathic medics but in vain.please suggest me the treatment. My all medical reprts are clear
The introduction of selective serotonin reuptake inhibitors (SSRIs) revolutionized the treatment of premature ejaculation.4 In 1994, the first study of SSRIs in men with premature ejaculation demonstrated a delaying effect with paroxetine (Paxil).5 Since that time, SSRIs have been repeatedly investigated for their propensity to delay ejaculation. Certain SSRIs and the tricyclic antidepressant clomipramine (Anafranil) have become the agents of choice for the treatment of premature ejaculation.6
I am Ahmed and am 60 years of age. Dr Sharma since the age of around 6 0r 8 I used to have high sexual desire which was due to some sexual agitation since then or earlier beneath my belly button area something wrong there. masturbation has been with me since then. at my marriage I was suffering from PE and Soft erection. I had a severe life that I could not do sex and on the other hand i had extreme sexual desire that could not be fulfilled. I am still suffering from PE and Ed now. I cannot take Honey, Dates, Gram, beef , fish my face tightens up and my tolerance level decreases drastically and my annoyance go very high.
i am 62 years old male. for the last 2 years i have erectile problem particularly during evening and it is very depressing.on account of erectile problem i am losing interest in sex. i have one more problem and that is of early ejaculation. this problem is since adulthood.i am on hypertensive medication for the last 7 years . i have no other medical problem. however my digestive system is also weak which probably is the cause of hyperacidity i am suffering from.is there any treatment for erectile problem and earliy ejaculation
Several PDE 5 inhibitors are currently being evaluated in clinical studies. Avanafil is an ultra short-acting agent that is rapidly absorbed (Tmax 35 min) and eliminated (T1/2 < 1.5 hrs) and therefore may be an effective treatment option in patients who require nitrate therapy. Udenafil, mirodenafil, and slx-2101 have also shown improvement in erectile function, and udenafil's potential to modify the underlying ED pathology is being investigated.35
5. Top Stimulation: This is another exercise that is typically done alone, although you could always have your partner assist you. It involves stroking your penis, but only the very tip where the bulk of the nerves are located. You should stimulate the penis in quick, shallow strokes and when you feel the urge to climax building, stop immediately. This is incredibly similar to edging. The only difference is the use of only part of the penis instead of your full length. Many men prefer this method because they say it is easier to control the climax; therefore, it is often more successful in building sexual stamina. You can repeat this method over and over, as many times as you like.

I have had a sad life in the regard of sexual dysfunction as ED started for me at 29 and have problems all my life. Never lasted more than a minute or two without the use of very strong anesthetics. The problem is then I cannot ejaculate by such usage. At age of 60+, I underwent penile implant operation. Now firmness not an issue but PE persists. Tried antidepressants but they are of no use. Implants means your simulated erection does not go away after ejaculation but it is tough to get another one. With implant, you remain firm after ejaculation but there is no pleasure. I have problems with Chinese medicines because they cause high blood pressure for me and I have taken blood pressure pills for 40. J years. Just curious as to what your medicine says about my case.
Due to excessive sex desire i have abused my self with masturbation and due to which may be iam having these problems, shriviled penis even after erection it is 4inch and the dia is 3 inch, early discharge and premature ejaculation also. The early discharge is on thinking or feeling about having sex. But after that also there is ejaculation but it finishes in seconds , please advice me which homeo medicines should i take to at least safe guard my next marriage.
Homeopathic medicine for premature ejaculation can be divided with their symptoms such as weakness, diminished libido, diminished power, impotency and sexual excesses (loss of memory, impaired coordination, numbness and tingling in limbs, irresistible desire for masturbation, constant dwelling on sexual subjects and excitable even before the sexual stimulation starts):
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